901 ACQUIRED VON WILLEBRAND'S DISEASE (vWD) SECONDARY TO SPLENIC HEMANGIOMA

From hamartoma to splenic hemangioma.

Vascular benign lesions are the most common non-hematological splenic primary tumors. Although rare they may sometimes pose problems in differential diagnosis, because of their morphologic heterogeneity. We present vascular lesions of the spleen, which were found in archive of the Chair of Pathomorphology. Immunohistochemistry including CD34, CD31, factor VIII, CD8, CD21, CD68, lysosyme, GLUT-1...

Von Willebrand Disease (VWD, Angiohemophilia) — Classification and Treatment

Von Willebrand Disease (VWD, Angiohemophilia) — Classification and Treatment

Von Willebrand Disease (VWD, Angiohemophilia) — Classification and Treatment

Splenic Marginal Zone Lymphoma with Acquired von Willebrand Syndrome Diagnosed via Splenic Bleeding

An 85-year-old woman underwent emergent splenectomy due to left abdominal pain and active bleeding in a massively enlarged spleen. The histological diagnosis was splenic marginal zone lymphoma (SMZL). A prolonged activated partial thromboplastin time (APTT) was noted, and additional tests led to the diagnosis of type 2A-like acquired von Willebrand syndrome (AVWS). An APTT cross mixing test rul...